Wrinkles

... ScienceDaily: Newly Discovered Small Molecules 'Superactivate' Botox @import "/styles/tabs.css"; Show menu RSS feeds | Free newsletter Source: Scripps Research Institute Posted: March 14, 2006 Newly Discovered Small Molecules 'Superactivate' Botox Scientists at The Scripps Research Institute have discovered several small molecules that can "superactivate" the botulinum neurotoxin (BoNT), the commonly used cosmetic treatment for wrinkles known as Botox that has a number of therapeutic uses.

According to the study, these activators bind to specific sites on the neurotoxin protein, increasing protease activity and enhancing the toxin's effect.

In some cases, the study noted, the activation power of the new molecules was as much as fourteen-fold, the greatest increase in activation ever reported for a protease; before this study, a two-fold activation of a protease was referred to as a state of "superactivation." Proteases are enzymes that act as cellular catalysts, breaking up proteins into smaller elements such as amino acids and reducing the amount of energy needed for the activation.

The study was released in an advanced online version by the Journal of the American Chemical Society.

Kim Janda, currently the Ely R.

Callaway Jr.

professor of chemistry, director of the Worm Institute for Research and Medicine (WIRM), and head of the laboratory that conducted the study, said, "Since the botulinum neurotoxin is the most poisonous toxin known, finding a compound to activate i...

... Telegraph Make us your homepage Search Our site Web Search Our site Web Wednesday 15 March 2006 Home News home Breaking news Business news Crossword Society Factfiles Law reports Matt cartoon Obituaries Opinion Picture galleries Quiz Text alerts Weather Weblogs Week at a glance Your view SPECIAL REPORTSMarriott HotelsVodafone PassportHitachi TechnologyEnergy Saving TrustClimate change: BP About us Contact us First volunteers sought for UK Biobank projectBy Roger Highfield, Science Editor(Filed: 15/03/2006) The world's largest medical experiment was launched yesterday in Altrincham, Cheshire, with the first 3,000 of a target half a million people invited to take part.

UK Biobank is a "visionary project" aimed at improving the prevention, diagnosis and treatment of cancer, heart disease, diabetes, dementia, joint disease and many other serious illnesses for generations to come, say the Government and the Wellcome Trust charity.

One researcher likened it to an "epidemiological microscope" that will reveal why some people will die before they get old.

But the project has attracted controversy over its long gestation.

One of its initial critics, Prof Sir Alec Jeffreys of the University of Leicester, inventor of DNA fingerprinting, said yesterday that his misgivings had now been "largely allayed" by the organisers.

Ho...

... Jokinen Thrilled to Stay the Course With Panthers - Los Angeles Times 1:00 AM PST, March 14, 2006 Weather Traffic Jobs Cars Real Estate Apartments Shopping HOME Site Map Sports Sports Extra Columnists Morning Briefing Letters Angels Dodgers Lakers Local National World Entertainment News Business Sports Politics Opinion Columnists Print Edition What is RSS?

Calendarlive Travel West Magazine House & Home Health Food Car Culture Obituaries Crossword, Sudoku All Sections Corrections Buy, Sell & More Jobs Cars Real Estate Apartments Personals Deals at Local Stores Coupons Newspaper Ads Place an Ad Member Services Sign Up Log In Help Contact Us L.A.

Times Archives HOME DELIVERY Customer Support Subscribe to L.A.

Times Sports Print E-mail story Most e-mailed Change text size SPORTS EXTRA / HOCKEY Jokinen Thrilled to Stay the Course With Panthers By Helene Elliott, Times Staff Writer March 14, 2006 Florida center Olli Jokinen is in his eighth NHL season and has yet to play in a playoff game.

That probably won't change this season, with the Panthers nine points out of the top eight in the East with 18 games to play.But Jokinen, who ranks among the NHL's top 15 scorers with 32 goals and a career-high 71 points, said h...